This policy brief examines the impact of ACEs in the health system including promising practices and recommended actions for change. The brief was developed by members of the Illinois ACEs Response Collaborative—system leaders in Illinois who are working from an ACEs-informed lens to improve systems to prevent and mitigate trauma across generations. Rooted in social justice, the brief is a call to action to move upstream, build resiliency, and recognize how addressing inequity and trauma can improve systems while also building resiliency.